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Contemporary coronary artery bypass grafting

null

《医学前沿（英文）》 2014年 第8卷 第4期   页码 395-398 doi: 10.1007/s11684-014-0374-7

摘要：

Current evidence clearly demonstrates that coronary artery bypass grafting (CABG) remains the “gold standard” treatment for most patients with multivessel and left main stem disease. This article summarizes the relevant evidence basis demonstrating that CABG, in comparison to stenting, reduces mortality and subsequent myocardial infarction and the need for repeat revascularization. The article also describes the evidence basis to support the use of more arterial grafts during CABG and the current role of off-pump CABG.

关键词： coronary artery bypass grafting (CABG)     coronary artery disease     left main     arterial grafts     internal mammary artery     off-pump CABG    

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Investigation on the mechanism of ginsenoside Rg3 in treating murine primary mammary tumor

Hongbo TANG MD, Zirong YE MM, Yuping REN MD, Zhanyong ZHU MD, Yiping WU MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 421-425 doi: 10.1007/s11684-009-0078-6

摘要： A murine primary mammary tumor model was established to investigate the treatment with ginsenosides Rg3. The relationship between ginsenosides Rg3 and primary mammary tumor was explored. Mammary tumor was induced by using the 7,12-dimethybenz(a)anthracene (DMBA). Ginsenoside Rg3 was employed for treatment. The incidence of mammary tumor in every group was compared, and the expressions of vascular endothelial growth factor (VEGF) and microvessel density (MVD) were detected by immunohistochemical method. The cell cycle and apoptosis percentage were determined by means of flow cytometry. The incidence of tumor in treatment group was significantly lower than that in control group (60.00% 33.33%, <0.05). The average diameter of mammary tumor was (0.86±0.27) cm in control group and (0.39±0.09) cm in treatment group, with the difference being significant between control and treatment groups (<0.01). The MVD value was (31.9±5.3) in control group and (20.1±4.9) in treatment group, respectively. There was a significant difference between the two groups (<0.05). The apoptosis percentage in control group was significantly lower than that in treatment group [(2.47±0.69)% (5.67±0.99)%, <0.05]. Ginsenoside Rg3 can play an antitumor role in primary mammary tumor model by inhibiting angiogenesis, cell cycle progression, and promoting cell apoptosis.

关键词： ginsenoside Rg3     mammary tumor     mice    

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Coronary leukocyte activation in relation to progression of coronary artery disease

null

《医学前沿（英文）》 2016年 第10卷 第1期   页码 85-90 doi: 10.1007/s11684-016-0435-1

摘要：

Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.

关键词： coronary artery disease     inflammation     integrin     myeloperoxidase     leukocyte activation    

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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery

null

《医学前沿（英文）》 2011年 第5卷 第1期   页码 86-93 doi: 10.1007/s11684-011-0118-x

摘要：

Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.

关键词： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

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Cylindrical particulate internal flows: A review

Lizhong HUANG, Xiang GAO, Jianzhong LIN

《机械工程前沿（英文）》 2012年 第7卷 第4期   页码 385-393 doi: 10.1007/s11465-012-0354-z

摘要：

The study of cylindrical particulate internal flows has wide industrial applicability hence received much attention. This article reviews the cylindrical particulate internal flows over the past twenty years. The research is related to the cylindrical particulate flows in the straight channel, curved channel and rotational channel. Finally, several open research issues have been identified.

关键词： cylindrical particulate flow     internal flow    

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SinoSCORE: a logistically derived additive prediction model for post-coronary artery bypass grafting

null

《医学前沿（英文）》 2013年 第7卷 第4期   页码 477-485 doi: 10.1007/s11684-013-0284-0

摘要：

This study aims to construct a logistically derived additive score for predicting in-hospital mortality risk in Chinese patients undergoing coronary artery bypass surgery (CABG). Data from 9839 consecutive CABG patients in 43 Chinese centers were collected between 2007 and 2008 from the Chinese Coronary Artery Bypass Grafting Registry. This database was randomly divided into developmental and validation subsets (9:1). The data in the developmental dataset were used to develop the model using logistic regression. Calibration and discrimination characteristics were assessed using the validation dataset. Thresholds were defined for each model to distinguish different risk groups. After excluding 275 patients with incomplete information, the overall mortality rate of the remaining 9564 patients was 2.5%. The SinoSCORE model was constructed based on 11 variables: age, preoperative NYHA stage III or IV, chronic renal failure, extracardiac arteriopathy, chronic obstructive pulmonary disease, preoperative atrial fibrillation or flutter (within 2βweeks), left ventricular ejection fraction, other elective surgery, combined valve procedures, preoperative critical state, and BMI. In the developmental dataset, calibration using a Hosmer-Lemeshow (HL) test was at =β0.44 and discrimination based on the area under the receiver operating characteristic curve (ROC) was 0.80. In the validation dataset, the HL test was at =β0.34 and the area under the ROC (AUC) was 0.78. A logistically derived additive model for predicting in-hospital mortality among Chinese patients undergoing CABG was developed based on the most up-to-date multi-center data from China.

关键词： coronary artery bypass grafting     risk stratification     in-hospital mortality    

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Current progress on internal medicine in China—2006 Part I

YAO Dingkang, ZHU Liang, ZHAO Xue, MEI Changlin

《医学前沿（英文）》 2007年 第1卷 第3期   页码 235-247 doi: 10.1007/s11684-007-0046-y

摘要： The growing interest has been placed in the current state of Chinaºs internal medicine from all over the world. Many data of internal medicine in China were collected by searching through some of the most prominent medical magazines published in China in 2006. Because there are many researches on the field of internal medicine, just some representative reports focusing on this topic were selected in this paper. In part I of this study, a summary of the advances made in cardiology, respiration diseases, and gastroenterology was presented.

关键词： internal medicine     Chinaºs internal     respiration     gastroenterology     cardiology    

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Treatment of severe diffuse cavernous hemangioma of the lower limb by combination of superficial femoral artery

Yin XIA, Dan SHANG, Qin LI, Xiaoqin RUN, Chenxi OUYANG, Yiqing LI, Bi JIN

《医学前沿（英文）》 2009年 第3卷 第2期   页码 240-244 doi: 10.1007/s11684-009-0031-8

摘要： Severe diffuse cavernous hemangioma of the lower limb is rarely seen among young people and sometimes can be a fatal challenge for operation. We reported a case of diffuse cavernous hemangioma involving both skin and muscles of the left lower limb and perineal region in an adolescent patient. The patient who had previously undergone a local hemangioma resection of the foot ultimately ended in superficial femoral artery ligation and supergenual thigh amputation of the left upper leg because of uncontrollable massive bleeding of anastomotic stoma.

关键词： cavernous hemangioma     femoral artery     ligation     amputation    

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Unified cycle model of a class of internal combustion engines and their optimum performance characteristics

Shiyan ZHENG

《能源前沿（英文）》 2011年 第5卷 第4期   页码 367-375 doi: 10.1007/s11708-011-0170-x

摘要： The unified cycle model of a class of internal combustion engines is presented, in which the influence of the multi-irreversibilities mainly resulting from the adiabatic processes, finite-time processes and heat leak loss through the cylinder wall on the performance of the cycle are taken into account. Based on the thermodynamic analysis method, the mathematical expressions of the power output and efficiency of the cycle are calculated and some important characteristic curves are given. The influence of the various design parameters such as the high-low pressure ratio, the high-low temperature ratio, the compression and expansion isentropic efficiencies etc. on the performance of the cycle is analyzed. The optimum criteria of some important parameters such as the power output, efficiency and pressure ratio are derived. The results obtained from this unified cycle model are very general and useful, from which the optimal performance of the Atkinson, Otto, Diesel, Dual and Miller heat engines and some new heat engines can be directly derived.

关键词： internal combustion engine     irreversibility     power output     efficiency     optimization    

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An Empirical Study on the Internal Control Efficiency of Listed Engineering Companies

Zhi-wen Wang,Jing Tong

《工程管理前沿（英文）》 2015年 第2卷 第2期   页码 159-164 doi: 10.15302/J-FEM-2015026

摘要： The authors carried out an empirical study on the internal control efficiency of publically listed engineering companies in China. This study presents an exploration of the relationship of independent director ratios, audit committee quality and auditor independence with the internal control efficiency of publically listed engineering companies and forward suggestions and recommendations on raising the internal control efficiency of publically listed engineering companies.

关键词： internal control efficiency     board of directors     independent directors     audit committee    

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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

《医学前沿（英文）》 2023年 第17卷 第1期   页码 75-84 doi: 10.1007/s11684-022-0950-1

摘要： This retrospective single-center registry study included all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo left main coronary artery lesion using drug coated-balloon (DCB)-only strategy between August 2011 and December 2018. To best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main coronary artery disease, exist. The primary endpoint was major adverse cardiovascular events (MACEs) including cardiac death, non-fatal myocardial infarction, and target lesion revascularization (TLR). The cohort was divided into two groups depending on weather the lesion preparation was done according to the international consensus group guidelines. Sixty-six patients (mean age 75±8.6, 72% male), 52% of whom had acute coronary syndrome, underwent left main PCI with the DCB-only strategy. No procedural mortality and no acute closures of the treated left main occurred. At 12 months, MACE and TLR occurred in 24% and 6% of the whole cohort, respectively. If the lesion preparation was done according to the guidelines, the MACE and TLR rates were 21.2% and 1.9%. Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one year, if the lesion preparation is done according to the guidelines.

关键词： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary intervention    

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Embankment dam foundation analysis for the decrease of internal erosion likelihood

Marc SMITH

《结构与土木工程前沿（英文）》 2012年 第6卷 第4期   页码 431-436 doi: 10.1007/s11709-012-0183-5

摘要： A zoned embankment dam is founded on clay underlain by a sand deposit. Major seepage phenomena were noticed in the foundation downstream from the dam where the vertical seepage forces in the sand layer were expected to exceed the downward forces due to the overlying clay. Modern technologies were applied to delineate critical zones to help design optimal rehabilitation measures. A global electromagnetic survey was carried out to detect and map the main sources, pathways and exits of seepage. Based on these global findings, a more detailed analysis was then conducted to identify zones where thickness of the foundation clay is minimal, pore pressures in sand are higher and thus where the factor of safety against uplift is lower and internal erosion is more likely to occur. Clay thickness evaluation required the determination of land surface as well as clay-sand contact elevations. A laser airborne survey was performed to model the land surface elevation. Data concerning the clay-sand contact elevation came from the interpreted stratigraphy based on a series of boreholes and cone penetration tests. This data was combined in a geostatistical model along with the measured piezometric levels in the foundation. This resulted in a contour map showing factors of safety against uplift over the entire downstream area. The use of modern technologies, namely electromagnetic and laser surveys as well as geostatistical tools, was instrumental in defining the limits of an otherwise spread-out problem and to provide an optimal solution, in terms of costs and effectiveness, for the long-term stabilization of the foundation.

关键词： seepage detection     geostatistical analysis     dam monitoring     internal erosion     LIDAR survey    

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Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease

Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu

《医学前沿（英文）》 2020年 第14卷 第1期   页码 81-90 doi: 10.1007/s11684-019-0692-x

摘要： Accumulating evidence suggests that C-type lectin-like receptor-2 (CLEC-2) plays an important role in atherothrombosis. In this case-control study, we investigated the association between CLEC-2 and incidence of coronary artery disease (CAD). A total of 216 patients, including 14 cases of stable angina pectoris (SAP, non-ACS) and 202 cases of acute coronary syndrome (ACS), and 89 non-CAD control subjects were enrolled. Plasma levels of soluble CLEC-2 (sCLEC-2) were measured using the enzyme-linked immunosorbent assay (ELISA). Compared with the control group (65.69 (55.36–143.22) pg/mL), the plasma levels of sCLEC-2 were significantly increased in patients with CAD (133.67 (88.76–220.09) pg/mL) and ACS (134.16 (88.88–225.81) pg/mL). The multivariate adjusted odds ratios (95% confidence interval) of CAD reached 2.01 (1.52–2.66) ( <0.001) for each 1-quartile increase in sCLEC-2. Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence ( <0.001). The addition of sCLEC-2 to conventional risk factors improved the C statistic (0.821 vs. 0.761, = 0.004) and reclassification ability (net reclassification improvement: 57.45%, <0.001; integrated discrimination improvement: 8.27%, <0.001) for CAD. In conclusion, high plasma sCLEC-2 is independently associated with CAD risk, and the prognostic value of sCLEC-2 may be evaluated in future prospective studies.

关键词： soluble C-type lectin-like receptor-2     coronary artery disease     risk factor    

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Advances in polishing of internal structures on parts made by laser-based powder bed fusion

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0724-0

摘要： The internal structures of metallic products are important in realizing functional applications. Considering the manufacturing of inner structures, laser-based powder bed fusion (L-PBF) is an attractive approach because its layering principle enables the fabrication of parts with customized interior structures. However, the inferior surface quality of L-PBF components hinders its productization progress seriously. In this article, process, basic forms, and applications relevant to L-PBF internal structures are reviewed comprehensively. The causes of poor surface quality and differences in the microstructure and property of the surface features of L-PBF inner structures are presented to provide a perspective of their surface characteristics. Various polishing technologies for L-PBF components with inner structures are presented, whereas their strengths and weaknesses are summarized along with a discussion on the challenges and prospects for improving the interior surface quality of L-PBF parts.

关键词： laser-based powder bed fusion     polishing     internal structures     surface quality     surface features     post process     additive manufacturing    

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investigation of the chemical and electrochemical characteristics of planar solid oxide fuel cell with direct internal

Yuzhang WANG, Shilie WENG, Yiwu WENG

《能源前沿（英文）》 2011年 第5卷 第2期   页码 195-206 doi: 10.1007/s11708-011-0148-8

摘要： A fully three-dimensional mathematical model of a planar solid oxide fuel cell (SOFC) with complete direct internal steam reforming was constructed to investigate the chemical and electrochemical characteristics of the porous-electrode-supported (PES)-SOFC developed by the Central Research Institute of Electric Power Industry of Japan. The effective kinetic models developed over the Ni/YSZ anode takes into account the heat transfer and species diffusion limitations in this porous anode. The models were used to simulate the methane steam reforming processes at the co- and counter-flow patterns. The results show that the flow patterns of gas and air have certain effects on cell performance. The cell at the counter-flow has a higher output voltage and output power density at the same operating conditions. At the counter-flow, however, a high hotspot temperature is observed in the anode with a non-fixed position, even when the air inlet flow rate is increased. This is disadvantageous to the cell. Both cell voltage and power density decrease with increased air flow rate.

关键词： planar solid oxide fuel cell (SOFC)     direct internal reforming     chemical reaction     methane     electrochemical    

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标题 作者 时间 类型 操作

Contemporary coronary artery bypass grafting

null

期刊论文

Investigation on the mechanism of ginsenoside Rg3 in treating murine primary mammary tumor

Hongbo TANG MD, Zirong YE MM, Yuping REN MD, Zhanyong ZHU MD, Yiping WU MD,

期刊论文

Coronary leukocyte activation in relation to progression of coronary artery disease

null

期刊论文

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery

null

期刊论文

Cylindrical particulate internal flows: A review

Lizhong HUANG, Xiang GAO, Jianzhong LIN

期刊论文

SinoSCORE: a logistically derived additive prediction model for post-coronary artery bypass grafting

null

期刊论文

Current progress on internal medicine in China—2006 Part I

YAO Dingkang, ZHU Liang, ZHAO Xue, MEI Changlin

期刊论文

Treatment of severe diffuse cavernous hemangioma of the lower limb by combination of superficial femoral artery

Yin XIA, Dan SHANG, Qin LI, Xiaoqin RUN, Chenxi OUYANG, Yiqing LI, Bi JIN

期刊论文

Unified cycle model of a class of internal combustion engines and their optimum performance characteristics

Shiyan ZHENG

期刊论文

An Empirical Study on the Internal Control Efficiency of Listed Engineering Companies

Zhi-wen Wang,Jing Tong

期刊论文

Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

期刊论文

Embankment dam foundation analysis for the decrease of internal erosion likelihood

Marc SMITH

期刊论文

Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease

Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu

期刊论文

Advances in polishing of internal structures on parts made by laser-based powder bed fusion

期刊论文

investigation of the chemical and electrochemical characteristics of planar solid oxide fuel cell with direct internal

Yuzhang WANG, Shilie WENG, Yiwu WENG

期刊论文